| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_03680 | ISM_03925 | ISM_03680 | ISM_03925 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | Probable oxidoreductase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. | 0.627 |
| ISM_03680 | ISM_04990 | ISM_03680 | ISM_04990 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.670 |
| ISM_03680 | ISM_05000 | ISM_03680 | ISM_05000 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.616 |
| ISM_03680 | ISM_05875 | ISM_03680 | ISM_05875 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | phenylacetate-CoA ligase, putative; COG1541 Coenzyme F390 synthetase. | 0.702 |
| ISM_03680 | ISM_06100 | ISM_03680 | ISM_06100 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.699 |
| ISM_03680 | ISM_08325 | ISM_03680 | ISM_08325 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.618 |
| ISM_03680 | ISM_08755 | ISM_03680 | ISM_08755 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | COG1448 Aspartate/tyrosine/aromatic aminotransferase. | 0.686 |
| ISM_03680 | ISM_16740 | ISM_03680 | ISM_16740 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.693 |
| ISM_03680 | fumC | ISM_03680 | ISM_12420 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.710 |
| ISM_03680 | mdh | ISM_03680 | ISM_05055 | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.610 |
| ISM_03925 | ISM_03680 | ISM_03925 | ISM_03680 | Probable oxidoreductase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.627 |
| ISM_04990 | ISM_03680 | ISM_04990 | ISM_03680 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.670 |
| ISM_04990 | ISM_05000 | ISM_04990 | ISM_05000 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.999 |
| ISM_04990 | ISM_06100 | ISM_04990 | ISM_06100 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.404 |
| ISM_04990 | ISM_08325 | ISM_04990 | ISM_08325 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.548 |
| ISM_04990 | ISM_08755 | ISM_04990 | ISM_08755 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG1448 Aspartate/tyrosine/aromatic aminotransferase. | 0.807 |
| ISM_04990 | fumC | ISM_04990 | ISM_12420 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.996 |
| ISM_04990 | mdh | ISM_04990 | ISM_05055 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.956 |
| ISM_05000 | ISM_03680 | ISM_05000 | ISM_03680 | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | Hypothetical protein; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.616 |
| ISM_05000 | ISM_04990 | ISM_05000 | ISM_04990 | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |