Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_03755N-acylhomoserine lactone synthase; COG3916 N-acyl-L-homoserine lactone synthetase; Belongs to the autoinducer synthase family. (201 aa)    
Predicted Functional Partners:
ISM_06130
Modification methylase (Cytosine-specific methyltransferase; COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
 0.765
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
 0.764
mtnP
5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
     
  0.739
ISM_11085
Hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.
     
  0.739
ISM_03760
Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase.
 
  
 0.680
ISM_15650
Autoinducer-binding transcriptional regulator, LuxR family protein; COG2771 DNA-binding HTH domain-containing proteins.
  
 
 0.675
ISM_05685
Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
    
  0.666
ISM_15790
Transcriptional regulator, LuxR family/hydrolase, alpha/beta fold family; COG2771 DNA-binding HTH domain-containing proteins.
  
 
 0.655
ISM_02740
Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases.
  
  
 0.580
ISM_04465
Probable guanine deaminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases.
     
 0.524
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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