| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_03760 | ISM_03765 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.879 |
| ISM_03760 | ISM_04775 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.660 |
| ISM_03760 | ISM_04780 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | PAS; COG0642 Signal transduction histidine kinase. | 0.596 |
| ISM_03760 | ISM_05545 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.792 |
| ISM_03760 | ISM_06925 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.842 |
| ISM_03760 | ISM_10556 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.510 |
| ISM_03760 | ISM_12885 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.602 |
| ISM_03760 | ISM_12905 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.724 |
| ISM_03760 | ISM_15585 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Phosphate regulon sensor histidine kinase, putative; COG0642 Signal transduction histidine kinase. | 0.524 |
| ISM_03765 | ISM_03760 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.879 |
| ISM_03765 | ISM_04775 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.959 |
| ISM_03765 | ISM_04780 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | PAS; COG0642 Signal transduction histidine kinase. | 0.914 |
| ISM_03765 | ISM_05545 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.831 |
| ISM_03765 | ISM_06925 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.888 |
| ISM_03765 | ISM_10556 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.918 |
| ISM_03765 | ISM_12885 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.919 |
| ISM_03765 | ISM_12905 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.932 |
| ISM_03765 | ISM_13545 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0642 Signal transduction histidine kinase. | 0.842 |
| ISM_03765 | ISM_15585 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Phosphate regulon sensor histidine kinase, putative; COG0642 Signal transduction histidine kinase. | 0.881 |
| ISM_04775 | ISM_03760 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.660 |