| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_03765 | ISM_04775 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.986 |
| ISM_03765 | ISM_04780 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | PAS; COG0642 Signal transduction histidine kinase. | 0.933 |
| ISM_03765 | ISM_05545 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.943 |
| ISM_03765 | ISM_05910 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.913 |
| ISM_03765 | ISM_06040 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.905 |
| ISM_03765 | ISM_06925 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.942 |
| ISM_03765 | ISM_10556 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.933 |
| ISM_03765 | ISM_12885 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.938 |
| ISM_03765 | ISM_12905 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.950 |
| ISM_03765 | ISM_15585 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Phosphate regulon sensor histidine kinase, putative; COG0642 Signal transduction histidine kinase. | 0.923 |
| ISM_04775 | ISM_03765 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.986 |
| ISM_04775 | ISM_04780 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | PAS; COG0642 Signal transduction histidine kinase. | 0.933 |
| ISM_04775 | ISM_05545 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.880 |
| ISM_04775 | ISM_05910 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_04775 | ISM_06925 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.999 |
| ISM_04775 | ISM_10556 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.808 |
| ISM_04775 | ISM_12885 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.886 |
| ISM_04775 | ISM_12905 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.962 |
| ISM_04775 | ISM_15585 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Phosphate regulon sensor histidine kinase, putative; COG0642 Signal transduction histidine kinase. | 0.793 |
| ISM_04780 | ISM_03765 | PAS; COG0642 Signal transduction histidine kinase. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.933 |