| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02615 | ISM_03845 | ISM_02615 | ISM_03845 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | SIS domain protein; COG1737 Transcriptional regulators. | 0.402 |
| ISM_02615 | ISM_03915 | ISM_02615 | ISM_03915 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.799 |
| ISM_02615 | ISM_16955 | ISM_02615 | ISM_16955 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.799 |
| ISM_02615 | zwf | ISM_02615 | ISM_16500 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.879 |
| ISM_03840 | ISM_03845 | ISM_03840 | ISM_03845 | Polar amino acid uptake family ABC transporter, periplasmic substrate-binding protein; COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Belongs to the bacterial solute-binding protein 3 family. | SIS domain protein; COG1737 Transcriptional regulators. | 0.496 |
| ISM_03845 | ISM_02615 | ISM_03845 | ISM_02615 | SIS domain protein; COG1737 Transcriptional regulators. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.402 |
| ISM_03845 | ISM_03840 | ISM_03845 | ISM_03840 | SIS domain protein; COG1737 Transcriptional regulators. | Polar amino acid uptake family ABC transporter, periplasmic substrate-binding protein; COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Belongs to the bacterial solute-binding protein 3 family. | 0.496 |
| ISM_03845 | ISM_03915 | ISM_03845 | ISM_03915 | SIS domain protein; COG1737 Transcriptional regulators. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.524 |
| ISM_03845 | ISM_16955 | ISM_03845 | ISM_16955 | SIS domain protein; COG1737 Transcriptional regulators. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.524 |
| ISM_03845 | rbsK | ISM_03845 | ISM_06670 | SIS domain protein; COG1737 Transcriptional regulators. | Putative RbsK, Carbohydrate kinase, ribokinase family protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.415 |
| ISM_03845 | zwf | ISM_03845 | ISM_16500 | SIS domain protein; COG1737 Transcriptional regulators. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.407 |
| ISM_03915 | ISM_02615 | ISM_03915 | ISM_02615 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.799 |
| ISM_03915 | ISM_03845 | ISM_03915 | ISM_03845 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | SIS domain protein; COG1737 Transcriptional regulators. | 0.524 |
| ISM_03915 | ISM_16955 | ISM_03915 | ISM_16955 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.997 |
| ISM_03915 | zwf | ISM_03915 | ISM_16500 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.761 |
| ISM_16955 | ISM_02615 | ISM_16955 | ISM_02615 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.799 |
| ISM_16955 | ISM_03845 | ISM_16955 | ISM_03845 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | SIS domain protein; COG1737 Transcriptional regulators. | 0.524 |
| ISM_16955 | ISM_03915 | ISM_16955 | ISM_03915 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.997 |
| ISM_16955 | zwf | ISM_16955 | ISM_16500 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.761 |
| rbsK | ISM_03845 | ISM_06670 | ISM_03845 | Putative RbsK, Carbohydrate kinase, ribokinase family protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | SIS domain protein; COG1737 Transcriptional regulators. | 0.415 |
