Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_04165COG0642 Signal transduction histidine kinase. (456 aa)    
Predicted Functional Partners:
ISM_04170
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.983
ISM_06925
Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase.
  
 0.890
ISM_05245
Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
    
 0.871
ISM_07925
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.871
ISM_05915
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.852
ISM_03915
2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit.
    
 0.839
ISM_16955
Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit.
    
 0.839
ISM_13540
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.832
ISM_15615
Phosphate regulon transcriptional regulatory protein PhoB; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.824
ISM_01215
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.801
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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