Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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ISM_04550DNA-3-methyladenine glycosylase II, putative; COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase. (209 aa)    
Predicted Functional Partners:
ISM_03500
COG0350 Methylated DNA-protein cysteine methyltransferase.
 
 
 0.918
ISM_04545
Phospholipase/carboxylesterase family protein; COG0400 Predicted esterase.
     
 0.823
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.780
ISM_04555
Transporter, putative; COG0477 Permeases of the major facilitator superfamily.
     
 0.768
ISM_07430
Exodeoxyribonuclease III, putative; COG0708 Exonuclease III.
   
 0.730
ISM_16465
COG0708 Exonuclease III.
   
 0.730
ISM_10226
ADA regulatory protein; COG2207 AraC-type DNA-binding domain-containing proteins.
 
 
 0.712
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 
 0.707
ISM_11260
Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair.
  
 
 0.693
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
    
 
 0.681
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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