STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folE2Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (366 aa)    
Predicted Functional Partners:
ISM_13435
COG0720 6-pyruvoyl-tetrahydropterin synthase.
    
 0.964
ribA
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
     
 0.908
ISM_00215
Hypothetical protein; COG2199 FOG: GGDEF domain.
   
 
  0.854
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
     
 0.833
ISM_09856
Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase.
 
  
 0.828
ISM_02615
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.800
ISM_09861
Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
  
 0.625
ISM_06925
Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase.
    
  0.624
ISM_16830
Hypothetical protein.
  
     0.614
ISM_15205
N-acetylmuramoyl-L-alanine amidase, family 3; COG0860 N-acetylmuramoyl-L-alanine amidase.
  
  
 0.593
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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