| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01215 | ISM_01565 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | 0.493 |
| ISM_01215 | ISM_03740 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.500 |
| ISM_01215 | ISM_03765 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.484 |
| ISM_01215 | ISM_04770 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.723 |
| ISM_01215 | ISM_04775 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.986 |
| ISM_01215 | ISM_04790 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein rsbU; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.834 |
| ISM_01215 | ISM_05910 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.924 |
| ISM_01215 | ISM_06625 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.674 |
| ISM_01215 | ISM_06925 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.944 |
| ISM_01215 | ISM_07425 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.607 |
| ISM_01565 | ISM_01215 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.493 |
| ISM_01565 | ISM_03740 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.493 |
| ISM_01565 | ISM_03765 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.493 |
| ISM_01565 | ISM_04770 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.493 |
| ISM_01565 | ISM_04775 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.989 |
| ISM_01565 | ISM_04790 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sigma factor sigB regulation protein rsbU; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.493 |
| ISM_01565 | ISM_05910 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.794 |
| ISM_01565 | ISM_06625 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.941 |
| ISM_01565 | ISM_06925 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.970 |
| ISM_01565 | ISM_07425 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.941 |