| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00215 | ISM_01565 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | 0.966 |
| ISM_00215 | ISM_04775 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.959 |
| ISM_00215 | ISM_04845 | Hypothetical protein; COG2199 FOG: GGDEF domain. | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | 0.715 |
| ISM_00215 | ISM_04850 | Hypothetical protein; COG2199 FOG: GGDEF domain. | COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.707 |
| ISM_00215 | ISM_04860 | Hypothetical protein; COG2199 FOG: GGDEF domain. | WD domain/cytochrome c family protein; COG2319 FOG: WD40 repeat. | 0.424 |
| ISM_00215 | ISM_05545 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.964 |
| ISM_00215 | ISM_05910 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.987 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_01565 | ISM_00215 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.966 |
| ISM_01565 | ISM_04775 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.946 |
| ISM_01565 | ISM_04845 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | 0.587 |
| ISM_01565 | ISM_05545 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.971 |
| ISM_01565 | ISM_05855 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Possible FlgD protein; Required for flagellar hook formation. May act as a scaffolding protein. | 0.515 |
| ISM_01565 | ISM_05910 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.706 |
| ISM_01565 | ISM_06925 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.897 |
| ISM_04775 | ISM_00215 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.959 |
| ISM_04775 | ISM_01565 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | 0.946 |
| ISM_04775 | ISM_04845 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | 0.659 |
| ISM_04775 | ISM_04850 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.565 |
| ISM_04775 | ISM_04860 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | WD domain/cytochrome c family protein; COG2319 FOG: WD40 repeat. | 0.713 |