| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00215 | ISM_00280 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | 0.929 |
| ISM_00215 | ISM_04845 | Hypothetical protein; COG2199 FOG: GGDEF domain. | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | 0.715 |
| ISM_00215 | ISM_04850 | Hypothetical protein; COG2199 FOG: GGDEF domain. | COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.707 |
| ISM_00215 | ISM_05910 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.987 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_00215 | ISM_11180 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport sensor protein dctB; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.752 |
| ISM_00215 | ISM_12905 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.861 |
| ISM_00215 | ISM_16630 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.480 |
| ISM_00215 | ISM_16640 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.437 |
| ISM_00280 | ISM_00215 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.929 |
| ISM_00280 | ISM_04845 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | 0.516 |
| ISM_00280 | ISM_04850 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.623 |
| ISM_00280 | ISM_05910 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.983 |
| ISM_00280 | ISM_06925 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.991 |
| ISM_00280 | ISM_12905 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.894 |
| ISM_00280 | ISM_16630 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.662 |
| ISM_00650 | ISM_04850 | Transcriptional regulatory protein; COG3284 Transcriptional activator of acetoin/glycerol metabolism. | COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.784 |
| ISM_04845 | ISM_00215 | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.715 |
| ISM_04845 | ISM_00280 | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | 0.516 |
| ISM_04845 | ISM_04850 | ATP-binding region, ATPase-like:Histidine kinase, HAMPregion:Histidine kinase A, N-terminal; COG0642 Signal transduction histidine kinase. | COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.932 |