| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02655 | ISM_02665 | ISM_02655 | ISM_02665 | COG2857 Cytochrome c1. | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.999 |
| ISM_02655 | ISM_04975 | ISM_02655 | ISM_04975 | COG2857 Cytochrome c1. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.951 |
| ISM_02655 | ISM_04990 | ISM_02655 | ISM_04990 | COG2857 Cytochrome c1. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.949 |
| ISM_02655 | ISM_05000 | ISM_02655 | ISM_05000 | COG2857 Cytochrome c1. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.725 |
| ISM_02655 | ISM_05245 | ISM_02655 | ISM_05245 | COG2857 Cytochrome c1. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.778 |
| ISM_02655 | ISM_06040 | ISM_02655 | ISM_06040 | COG2857 Cytochrome c1. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.998 |
| ISM_02655 | ISM_12320 | ISM_02655 | ISM_12320 | COG2857 Cytochrome c1. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.722 |
| ISM_02655 | sucD | ISM_02655 | ISM_05065 | COG2857 Cytochrome c1. | succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.735 |
| ISM_02665 | ISM_02655 | ISM_02665 | ISM_02655 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | COG2857 Cytochrome c1. | 0.999 |
| ISM_02665 | ISM_04975 | ISM_02665 | ISM_04975 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.975 |
| ISM_02665 | ISM_04990 | ISM_02665 | ISM_04990 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.985 |
| ISM_02665 | ISM_05000 | ISM_02665 | ISM_05000 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.845 |
| ISM_02665 | ISM_05245 | ISM_02665 | ISM_05245 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.766 |
| ISM_02665 | ISM_06040 | ISM_02665 | ISM_06040 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.997 |
| ISM_02665 | ISM_12320 | ISM_02665 | ISM_12320 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.837 |
| ISM_02665 | sucD | ISM_02665 | ISM_05065 | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.759 |
| ISM_04975 | ISM_02655 | ISM_04975 | ISM_02655 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG2857 Cytochrome c1. | 0.951 |
| ISM_04975 | ISM_02665 | ISM_04975 | ISM_02665 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Ubiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.975 |
| ISM_04975 | ISM_04990 | ISM_04975 | ISM_04990 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |
| ISM_04975 | ISM_04995 | ISM_04975 | ISM_04995 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. | 0.997 |
