| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_03915 | ISM_05005 | ISM_03915 | ISM_05005 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | 0.613 |
| ISM_03915 | ISM_05015 | ISM_03915 | ISM_05015 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.493 |
| ISM_03915 | ISM_05020 | ISM_03915 | ISM_05020 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Sorbitol dehydrogenase, putative; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | 0.761 |
| ISM_03915 | ISM_06100 | ISM_03915 | ISM_06100 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.466 |
| ISM_03915 | ISM_16955 | ISM_03915 | ISM_16955 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.997 |
| ISM_05005 | ISM_03915 | ISM_05005 | ISM_03915 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.613 |
| ISM_05005 | ISM_05015 | ISM_05005 | ISM_05015 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.784 |
| ISM_05005 | ISM_05020 | ISM_05005 | ISM_05020 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Sorbitol dehydrogenase, putative; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | 0.837 |
| ISM_05005 | ISM_06100 | ISM_05005 | ISM_06100 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.782 |
| ISM_05005 | ISM_13565 | ISM_05005 | ISM_13565 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Phosphocarrier protein HPr; COG1925 Phosphotransferase system, HPr-related proteins. | 0.794 |
| ISM_05005 | ISM_16955 | ISM_05005 | ISM_16955 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.613 |
| ISM_05005 | cysC | ISM_05005 | ISM_11065 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.667 |
| ISM_05005 | hisD-3 | ISM_05005 | ISM_05010 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.622 |
| ISM_05005 | pheT | ISM_05005 | ISM_02650 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | phenylalanyl-tRNA synthetase beta subunit; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.611 |
| ISM_05005 | ribB | ISM_05005 | ISM_00120 | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.627 |
| ISM_05015 | ISM_03915 | ISM_05015 | ISM_03915 | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.493 |
| ISM_05015 | ISM_05005 | ISM_05015 | ISM_05005 | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | Transcriptional regulator, LacI family protein; COG1609 Transcriptional regulators. | 0.784 |
| ISM_05015 | ISM_05020 | ISM_05015 | ISM_05020 | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | Sorbitol dehydrogenase, putative; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | 0.951 |
| ISM_05015 | ISM_06100 | ISM_05015 | ISM_06100 | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.634 |
| ISM_05015 | ISM_16955 | ISM_05015 | ISM_16955 | Gluconate 5-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.493 |