Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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Score
ISM_05040COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (286 aa)    
Predicted Functional Partners:
ISM_05030
Hypothetical protein; COG2030 Acyl dehydratase.
 
 
 0.945
ISM_08435
COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.
  
  
 
0.886
ISM_17015
COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.
  
  
 
0.884
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.883
sucD-2
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.862
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
    
 0.860
ISM_14155
Class II aldolase/adducin N-terminal domain protein; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases.
   
    0.810
ISM_05035
Hypothetical protein; COG5515 Uncharacterized conserved small protein.
       0.776
ISM_09586
Malate dehydrogenase; COG0281 Malic enzyme.
  
 
 0.762
ISM_06675
Phosphate acetyltransferase; COG0281 Malic enzyme.
  
 
 0.739
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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