Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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ISM_05230Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. (322 aa)    
Predicted Functional Partners:
ISM_05235
Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
   
 0.943
ISM_05225
Hypothetical protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
 
     0.808
ISM_13635
COG0167 Dihydroorotate dehydrogenase.
    
  0.620
ISM_13590
Hypothetical protein; COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components.
  
 
 0.611
ISM_12435
Hypothetical protein; COG0607 Rhodanese-related sulfurtransferase.
     
  0.603
ISM_07145
NADPH-dependent FMN reductase domain protein; COG0431 Predicted flavoprotein.
  
 0.584
ISM_14615
NADPH-dependent FMN reductase; COG0431 Predicted flavoprotein.
  
 0.584
ISM_07345
4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family.
 
 
 0.575
ISM_16740
Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins.
     
 0.557
phnN-2
Putative thymidine phosphorylase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
     
  0.555
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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