| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01950 | ISM_05235 | Hypothetical protein; COG2124 Cytochrome P450. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.687 |
| ISM_01950 | ISM_16730 | Hypothetical protein; COG2124 Cytochrome P450. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.967 |
| ISM_01950 | ISM_16740 | Hypothetical protein; COG2124 Cytochrome P450. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.997 |
| ISM_03775 | ISM_03780 | Hypothetical protein. | Possible transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. | 0.895 |
| ISM_03775 | ISM_05235 | Hypothetical protein. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.547 |
| ISM_03775 | ISM_08490 | Hypothetical protein. | Dioxygenase superfamily-like protein; COG0346 Lactoylglutathione lyase and related lyases. | 0.687 |
| ISM_03780 | ISM_03775 | Possible transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. | Hypothetical protein. | 0.895 |
| ISM_03780 | ISM_05225 | Possible transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. | Hypothetical protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | 0.468 |
| ISM_03780 | ISM_05235 | Possible transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.558 |
| ISM_03780 | ISM_08490 | Possible transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. | Dioxygenase superfamily-like protein; COG0346 Lactoylglutathione lyase and related lyases. | 0.498 |
| ISM_05225 | ISM_03780 | Hypothetical protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | Possible transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. | 0.468 |
| ISM_05225 | ISM_05230 | Hypothetical protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.808 |
| ISM_05225 | ISM_05235 | Hypothetical protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.778 |
| ISM_05230 | ISM_05225 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Hypothetical protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | 0.808 |
| ISM_05230 | ISM_05235 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.939 |
| ISM_05230 | ISM_08490 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Dioxygenase superfamily-like protein; COG0346 Lactoylglutathione lyase and related lyases. | 0.421 |
| ISM_05230 | ISM_16730 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.861 |
| ISM_05230 | ISM_16740 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.640 |
| ISM_05235 | ISM_01950 | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Hypothetical protein; COG2124 Cytochrome P450. | 0.687 |
| ISM_05235 | ISM_03775 | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Hypothetical protein. | 0.547 |