| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02615 | ISM_04665 | ISM_02615 | ISM_04665 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG3588 Fructose-1,6-bisphosphate aldolase. | 0.874 |
| ISM_02615 | ISM_05245 | ISM_02615 | ISM_05245 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.953 |
| ISM_02615 | ISM_05255 | ISM_02615 | ISM_05255 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.874 |
| ISM_02615 | ISM_13350 | ISM_02615 | ISM_13350 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0021 Transketolase; Belongs to the transketolase family. | 0.942 |
| ISM_02615 | eno | ISM_02615 | ISM_16480 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.997 |
| ISM_02615 | pgi | ISM_02615 | ISM_16490 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.985 |
| ISM_02615 | pgk | ISM_02615 | ISM_04660 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. | 0.938 |
| ISM_02615 | tal | ISM_02615 | ISM_03480 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. | 0.886 |
| ISM_02615 | tpiA | ISM_02615 | ISM_15455 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.921 |
| ISM_02615 | zwf | ISM_02615 | ISM_16500 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.903 |
| ISM_04665 | ISM_02615 | ISM_04665 | ISM_02615 | COG3588 Fructose-1,6-bisphosphate aldolase. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.874 |
| ISM_04665 | ISM_05245 | ISM_04665 | ISM_05245 | COG3588 Fructose-1,6-bisphosphate aldolase. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.867 |
| ISM_04665 | ISM_05255 | ISM_04665 | ISM_05255 | COG3588 Fructose-1,6-bisphosphate aldolase. | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.972 |
| ISM_04665 | ISM_13350 | ISM_04665 | ISM_13350 | COG3588 Fructose-1,6-bisphosphate aldolase. | COG0021 Transketolase; Belongs to the transketolase family. | 0.942 |
| ISM_04665 | eno | ISM_04665 | ISM_16480 | COG3588 Fructose-1,6-bisphosphate aldolase. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.914 |
| ISM_04665 | pgi | ISM_04665 | ISM_16490 | COG3588 Fructose-1,6-bisphosphate aldolase. | COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.936 |
| ISM_04665 | pgk | ISM_04665 | ISM_04660 | COG3588 Fructose-1,6-bisphosphate aldolase. | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. | 0.911 |
| ISM_04665 | tal | ISM_04665 | ISM_03480 | COG3588 Fructose-1,6-bisphosphate aldolase. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. | 0.940 |
| ISM_04665 | tpiA | ISM_04665 | ISM_15455 | COG3588 Fructose-1,6-bisphosphate aldolase. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.979 |
| ISM_04665 | zwf | ISM_04665 | ISM_16500 | COG3588 Fructose-1,6-bisphosphate aldolase. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.816 |