STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_05370AhpC/TSA family protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (162 aa)    
Predicted Functional Partners:
ISM_09185
Thiol-specific antioxidant protein; COG0450 Peroxiredoxin.
   
 0.943
ISM_12135
Glutathione-disulfide reductase; Maintains high levels of reduced glutathione.
 
  
 0.928
ISM_14260
COG0625 Glutathione S-transferase.
  
 
  0.921
ISM_02470
Cation transport protein ChaC, putative; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
  
  
  0.919
ISM_08600
Thiol:disulfide interchange protein, putative; COG0526 Thiol-disulfide isomerase and thioredoxins.
   
 0.911
gshB
COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family.
     
 0.911
ISM_11325
Periplasmic protein thiol:disulfide oxidoreductase, DsbE subfamily protein; COG0526 Thiol-disulfide isomerase and thioredoxins.
   
 0.911
ISM_02050
COG0625 Glutathione S-transferase; Belongs to the GST superfamily.
   
 
  0.908
ISM_02900
Hypothetical protein; COG0625 Glutathione S-transferase.
   
 
  0.908
ISM_07725
COG0625 Glutathione S-transferase.
   
 
  0.908
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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