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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dddPMetallopeptidase, family M24; Able to cleave dimethlysulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethlysulfonioproprionate lyase in vivo: the low activity with DMSP as substrate suggests that DMSP is not its native substrate. (446 aa)    
Predicted Functional Partners:
ISM_15245
Hypothetical protein; COG0466 ATP-dependent Lon protease, bacterial type.
  
     0.712
ISM_09311
Hypothetical protein.
  
     0.679
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
   0.634
ISM_12995
COG4583 Sarcosine oxidase gamma subunit.
  
  
  0.627
ISM_09656
COG4583 Sarcosine oxidase gamma subunit.
  
  
  0.618
ISM_11950
COG3239 Fatty acid desaturase.
  
     0.582
ISM_14570
Aminomethyl transferase family protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
 
 0.572
ISM_14575
Hypothetical protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
 
 0.568
ISM_08375
phytanoyl-CoA dioxygenase family protein; COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin.
  
  
 0.551
ISM_15250
Rieske 2Fe-2S family protein; COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit.
  
     0.546
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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