| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02890 | ISM_08445 | ISM_02890 | ISM_08445 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.984 |
| ISM_02890 | ISM_12620 | ISM_02890 | ISM_12620 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.622 |
| ISM_02890 | ISM_12630 | ISM_02890 | ISM_12630 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | COG1010 Precorrin-3B methylase. | 0.714 |
| ISM_02890 | ISM_12635 | ISM_02890 | ISM_12635 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | COG2099 Precorrin-6x reductase. | 0.473 |
| ISM_02890 | ISM_12640 | ISM_02890 | ISM_12640 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | precorrin-6Y C5,15-methyltransferase (decarboxylating); COG2241 Precorrin-6B methylase 1. | 0.788 |
| ISM_02890 | ISM_12650 | ISM_02890 | ISM_12650 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | COG2875 Precorrin-4 methylase; Belongs to the precorrin methyltransferase family. | 0.746 |
| ISM_02890 | ISM_13695 | ISM_02890 | ISM_13695 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobalamin biosynthetic protein CobC; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.977 |
| ISM_02890 | cobB-2 | ISM_02890 | ISM_12655 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.927 |
| ISM_02890 | cobD | ISM_02890 | ISM_13690 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.993 |
| ISM_02890 | cobQ | ISM_02890 | ISM_05590 | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.984 |
| ISM_08445 | ISM_02890 | ISM_08445 | ISM_02890 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.984 |
| ISM_08445 | ISM_12620 | ISM_08445 | ISM_12620 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.687 |
| ISM_08445 | ISM_12630 | ISM_08445 | ISM_12630 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | COG1010 Precorrin-3B methylase. | 0.750 |
| ISM_08445 | ISM_12635 | ISM_08445 | ISM_12635 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | COG2099 Precorrin-6x reductase. | 0.546 |
| ISM_08445 | ISM_12640 | ISM_08445 | ISM_12640 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | precorrin-6Y C5,15-methyltransferase (decarboxylating); COG2241 Precorrin-6B methylase 1. | 0.780 |
| ISM_08445 | ISM_12650 | ISM_08445 | ISM_12650 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | COG2875 Precorrin-4 methylase; Belongs to the precorrin methyltransferase family. | 0.749 |
| ISM_08445 | ISM_13695 | ISM_08445 | ISM_13695 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Cobalamin biosynthetic protein CobC; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.968 |
| ISM_08445 | cobB-2 | ISM_08445 | ISM_12655 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.975 |
| ISM_08445 | cobD | ISM_08445 | ISM_13690 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.984 |
| ISM_08445 | cobQ | ISM_08445 | ISM_05590 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.988 |