| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02740 | ISM_02745 | ISM_02740 | ISM_02745 | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | Histidine utilization repressor; COG2188 Transcriptional regulators. | 0.786 |
| ISM_02740 | ISM_07160 | ISM_02740 | ISM_07160 | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | COG3741 N-formylglutamate amidohydrolase. | 0.777 |
| ISM_02740 | hutH | ISM_02740 | ISM_05635 | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | COG2986 Histidine ammonia-lyase. | 0.785 |
| ISM_02740 | hutI | ISM_02740 | ISM_05640 | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | COG1228 Imidazolonepropionase and related amidohydrolases. | 0.981 |
| ISM_02740 | hutU | ISM_02740 | ISM_05630 | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.789 |
| ISM_02745 | ISM_02740 | ISM_02745 | ISM_02740 | Histidine utilization repressor; COG2188 Transcriptional regulators. | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | 0.786 |
| ISM_02745 | ISM_07160 | ISM_02745 | ISM_07160 | Histidine utilization repressor; COG2188 Transcriptional regulators. | COG3741 N-formylglutamate amidohydrolase. | 0.532 |
| ISM_02745 | gcvP | ISM_02745 | ISM_05725 | Histidine utilization repressor; COG2188 Transcriptional regulators. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.626 |
| ISM_02745 | hutH | ISM_02745 | ISM_05635 | Histidine utilization repressor; COG2188 Transcriptional regulators. | COG2986 Histidine ammonia-lyase. | 0.817 |
| ISM_02745 | hutI | ISM_02745 | ISM_05640 | Histidine utilization repressor; COG2188 Transcriptional regulators. | COG1228 Imidazolonepropionase and related amidohydrolases. | 0.881 |
| ISM_02745 | hutU | ISM_02745 | ISM_05630 | Histidine utilization repressor; COG2188 Transcriptional regulators. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.787 |
| ISM_04990 | ISM_07160 | ISM_04990 | ISM_07160 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG3741 N-formylglutamate amidohydrolase. | 0.423 |
| ISM_04990 | gcvP | ISM_04990 | ISM_05725 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.898 |
| ISM_04990 | hutH | ISM_04990 | ISM_05635 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG2986 Histidine ammonia-lyase. | 0.482 |
| ISM_04990 | hutU | ISM_04990 | ISM_05630 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.484 |
| ISM_05645 | hutH | ISM_05645 | ISM_05635 | Hypothetical protein; COG3443 Predicted periplasmic or secreted protein. | COG2986 Histidine ammonia-lyase. | 0.482 |
| ISM_05645 | hutI | ISM_05645 | ISM_05640 | Hypothetical protein; COG3443 Predicted periplasmic or secreted protein. | COG1228 Imidazolonepropionase and related amidohydrolases. | 0.482 |
| ISM_05645 | hutU | ISM_05645 | ISM_05630 | Hypothetical protein; COG3443 Predicted periplasmic or secreted protein. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.436 |
| ISM_07160 | ISM_02740 | ISM_07160 | ISM_02740 | COG3741 N-formylglutamate amidohydrolase. | Formiminoglutamate deiminase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. | 0.777 |
| ISM_07160 | ISM_02745 | ISM_07160 | ISM_02745 | COG3741 N-formylglutamate amidohydrolase. | Histidine utilization repressor; COG2188 Transcriptional regulators. | 0.532 |