STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_05650Putative periplasmic protein; COG1525 Micrococcal nuclease (thermonuclease) homologs. (207 aa)    
Predicted Functional Partners:
ISM_05295
Sterol desaturase-like protein; COG3000 Sterol desaturase.
   
    0.727
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.648
ISM_05655
Hypothetical protein.
       0.636
ISM_01945
Hypothetical protein.
   
    0.527
ISM_03075
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
   
    0.527
ISM_05645
Hypothetical protein; COG3443 Predicted periplasmic or secreted protein.
       0.455
ISM_11650
Hypothetical protein; COG3000 Sterol desaturase.
   
    0.443
ISM_14160
Hypothetical protein; COG3000 Sterol desaturase.
   
    0.443
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.423
ISM_11670
ATP-dependent helicase HrpB; COG1643 HrpA-like helicases.
  
 
 
 0.420
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.