Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (949 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
ISM_05735
Hypothetical protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase).
 0.999
ISM_07675
Hypothetical protein; COG0509 Glycine cleavage system H protein (lipoate-binding).
  
 0.998
ISM_04300
Putative aminomethyltransferase protein; Belongs to the GcvT family.
 
 0.995
ISM_09346
Sarcosine oxidase, alpha subunit family protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family.
 
 0.995
ISM_09661
Sarcosine oxidase, alpha subunit family protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family.
 
 0.995
ISM_12990
Sarcosine oxidase, alpha subunit family protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family.
 
 0.995
ISM_02705
FAD dependent oxidoreductase/aminomethyl transferase; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
  
 0.994
ISM_02725
Aminomethyl transferase family protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
  
 0.994
ISM_02920
FAD dependent oxidoreductase/aminomethyl transferase; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
  
 0.994
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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