Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ISM_05765Cobalamin synthesis protein/P47K:Cobalamin synthesis CobW, C-terminal; COG0523 Putative GTPases (G3E family). (297 aa)    
Predicted Functional Partners:
ISM_05770
Amidohydrolase-like protein; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold.
 
   
 0.812
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
    
 
 0.755
rpsN
Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.
 
 
 0.725
ISM_05775
D-aminoacylase (aspartate, glutamate etc); COG3653 N-acyl-D-aspartate/D-glutamate deacylase.
       0.718
ISM_05780
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component.
       0.714
ISM_05785
Probable DctMQ fusion protein (C4-dicarboxylate transporter); COG3090 TRAP-type C4-dicarboxylate transport system, small permease component.
       0.714
folE2
Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate.
  
  
 0.671
dksA
dnaK suppressor protein, putative; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.
  
  
 0.597
rpmB
COG0227 Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
  
  
 0.568
ISM_12640
precorrin-6Y C5,15-methyltransferase (decarboxylating); COG2241 Precorrin-6B methylase 1.
     
 0.526
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.