| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_06040 | ISM_06100 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.734 |
| ISM_06040 | ISM_06105 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.986 |
| ISM_06040 | ISM_12965 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.434 |
| ISM_06040 | ISM_13635 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | COG0167 Dihydroorotate dehydrogenase. | 0.851 |
| ISM_06040 | ISM_14325 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | NADH-quinone oxidoreductase, F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.987 |
| ISM_06040 | ISM_14700 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.971 |
| ISM_06100 | ISM_06040 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.734 |
| ISM_06100 | ISM_06105 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.999 |
| ISM_06100 | ISM_07475 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.931 |
| ISM_06100 | ISM_12965 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.978 |
| ISM_06100 | ISM_13635 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0167 Dihydroorotate dehydrogenase. | 0.822 |
| ISM_06100 | ISM_14325 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | NADH-quinone oxidoreductase, F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.404 |
| ISM_06100 | ISM_14700 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.917 |
| ISM_06100 | ISM_15335 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamine amidotransferase-like protein; COG0067 Glutamate synthase domain 1. | 0.946 |
| ISM_06100 | ISM_15345 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamate synthase large subunit-like protein; COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.931 |
| ISM_06100 | ISM_16935 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.931 |
| ISM_06105 | ISM_06040 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.986 |
| ISM_06105 | ISM_06100 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.999 |
| ISM_06105 | ISM_07475 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.983 |
| ISM_06105 | ISM_12965 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.875 |