Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ISM_06305Oxygen-insensitive NAD(P)H nitroreductase; COG0778 Nitroreductase. (222 aa)    
Predicted Functional Partners:
ISM_15725
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 
 0.736
ISM_04480
Hypothetical protein; COG2249 Putative NADPH-quinone reductase (modulator of drug activity B).
 
  
 0.601
ISM_08490
Dioxygenase superfamily-like protein; COG0346 Lactoylglutathione lyase and related lyases.
  
    0.569
ISM_08730
Nitroreductase family protein; COG0778 Nitroreductase.
     
 0.565
ISM_02075
AMP-binding protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.557
ISM_03020
AMP-ligase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.557
ISM_04335
malonyl-CoA synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.557
ISM_05120
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.557
ISM_07235
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.557
ISM_08315
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.557
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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