STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_06305Oxygen-insensitive NAD(P)H nitroreductase; COG0778 Nitroreductase. (222 aa)    
Predicted Functional Partners:
ISM_15725
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
    
 0.744
ISM_02075
AMP-binding protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.609
ISM_03020
AMP-ligase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.609
ISM_04335
malonyl-CoA synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.609
ISM_05120
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.609
ISM_07235
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.609
ISM_08315
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
   
   0.609
ISM_15690
Benzoate-coenzyme A ligase, putative; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
   
   0.609
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
   
 
 0.608
ISM_08490
Dioxygenase superfamily-like protein; COG0346 Lactoylglutathione lyase and related lyases.
  
    0.597
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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