| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_01185 | ISM_02060 | ISM_01185 | ISM_02060 | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.661 |
| ISM_01185 | ISM_04125 | ISM_01185 | ISM_04125 | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.661 |
| ISM_01185 | ISM_06100 | ISM_01185 | ISM_06100 | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.451 |
| ISM_01185 | ISM_06355 | ISM_01185 | ISM_06355 | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.605 |
| ISM_01185 | ISM_08180 | ISM_01185 | ISM_08180 | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.772 |
| ISM_01185 | ISM_16740 | ISM_01185 | ISM_16740 | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.968 |
| ISM_02060 | ISM_01185 | ISM_02060 | ISM_01185 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | 0.661 |
| ISM_02060 | ISM_04125 | ISM_02060 | ISM_04125 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.884 |
| ISM_02060 | ISM_06100 | ISM_02060 | ISM_06100 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.451 |
| ISM_02060 | ISM_06355 | ISM_02060 | ISM_06355 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.605 |
| ISM_02060 | ISM_08180 | ISM_02060 | ISM_08180 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.772 |
| ISM_02060 | ISM_16740 | ISM_02060 | ISM_16740 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.968 |
| ISM_04125 | ISM_01185 | ISM_04125 | ISM_01185 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Hypothetical protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. | 0.661 |
| ISM_04125 | ISM_02060 | ISM_04125 | ISM_02060 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.884 |
| ISM_04125 | ISM_06100 | ISM_04125 | ISM_06100 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.451 |
| ISM_04125 | ISM_06355 | ISM_04125 | ISM_06355 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.605 |
| ISM_04125 | ISM_08180 | ISM_04125 | ISM_08180 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.772 |
| ISM_04125 | ISM_16740 | ISM_04125 | ISM_16740 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.968 |
| ISM_05230 | ISM_06355 | ISM_05230 | ISM_06355 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Probable oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.548 |
| ISM_05230 | ISM_08180 | ISM_05230 | ISM_08180 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.479 |