Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_06370COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (372 aa)    
Predicted Functional Partners:
ISM_00270
NAD(P)+ transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
  
  0.948
ISM_15805
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
 
 0.945
ISM_04685
Serine--glyoxylate transaminase, putative; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase.
     
  0.850
ISM_17005
Probable serine-glyoxylate aminotransferase; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase.
     
  0.850
ISM_02615
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.767
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
    
 0.764
ISM_05245
Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
    
  0.740
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    
  0.740
ISM_01475
COG1794 Aspartate racemase.
     
  0.739
pdhA
Pyruvate dehydrogenase complex, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
  0.739
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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