| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_03915 | ISM_06370 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | 0.617 |
| ISM_03915 | ISM_06375 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.435 |
| ISM_03915 | ISM_16955 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.997 |
| ISM_06370 | ISM_03915 | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.617 |
| ISM_06370 | ISM_06375 | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.550 |
| ISM_06370 | ISM_16955 | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.617 |
| ISM_06375 | ISM_03915 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.435 |
| ISM_06375 | ISM_06370 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | 0.550 |
| ISM_06375 | ISM_15725 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.528 |
| ISM_06375 | ISM_16955 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.435 |
| ISM_15725 | ISM_06375 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.528 |
| ISM_16955 | ISM_03915 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.997 |
| ISM_16955 | ISM_06370 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. | 0.617 |
| ISM_16955 | ISM_06375 | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.435 |