Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_06835Hypothetical protein; COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases. (336 aa)    
Predicted Functional Partners:
ISM_06830
Nucleotidyltransferase family protein; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon).
 
 
 0.995
ISM_06840
Hypothetical protein; COG0802 Predicted ATPase or kinase.
      0.982
ISM_06825
Hypothetical protein; COG3893 Inactivated superfamily I helicase.
    
  0.889
glmU
UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
    
 0.872
ISM_06820
ATP-dependent DNA helicase, UvrD/Rep family protein; COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); Belongs to the helicase family. UvrD subfamily.
       0.845
ISM_14205
COG0546 Predicted phosphatases.
 
  
 0.764
ISM_06845
Hypothetical protein; COG2202 FOG: PAS/PAC domain.
       0.720
ISM_06815
Thioredoxin; COG0526 Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family.
       0.719
ISM_06850
COG0642 Signal transduction histidine kinase.
       0.605
ISM_16420
beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases.
 
   
 0.558
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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