| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00035 | ISM_00215 | Hypothetical protein; COG0457 FOG: TPR repeat. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.560 |
| ISM_00035 | ISM_06625 | Hypothetical protein; COG0457 FOG: TPR repeat. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.464 |
| ISM_00035 | ISM_06850 | Hypothetical protein; COG0457 FOG: TPR repeat. | COG0642 Signal transduction histidine kinase. | 0.692 |
| ISM_00035 | ISM_06925 | Hypothetical protein; COG0457 FOG: TPR repeat. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.814 |
| ISM_00215 | ISM_00035 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Hypothetical protein; COG0457 FOG: TPR repeat. | 0.560 |
| ISM_00215 | ISM_06625 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.985 |
| ISM_00215 | ISM_06845 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Hypothetical protein; COG2202 FOG: PAS/PAC domain. | 0.668 |
| ISM_00215 | ISM_06850 | Hypothetical protein; COG2199 FOG: GGDEF domain. | COG0642 Signal transduction histidine kinase. | 0.762 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_00215 | ISM_07420 | Hypothetical protein; COG2199 FOG: GGDEF domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.742 |
| ISM_03915 | ISM_05245 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
| ISM_03915 | ISM_06850 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | COG0642 Signal transduction histidine kinase. | 0.839 |
| ISM_03915 | ISM_06925 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.851 |
| ISM_03915 | ISM_16955 | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.997 |
| ISM_05245 | ISM_03915 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 2-oxoisovalerate dehydrogenase beta subunit; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.999 |
| ISM_05245 | ISM_06850 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | COG0642 Signal transduction histidine kinase. | 0.871 |
| ISM_05245 | ISM_06925 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.886 |
| ISM_05245 | ISM_16955 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Possible 2-oxoisovalerate dehydrogenase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.999 |
| ISM_06625 | ISM_00035 | Response regulator; COG0784 FOG: CheY-like receiver. | Hypothetical protein; COG0457 FOG: TPR repeat. | 0.464 |
| ISM_06625 | ISM_00215 | Response regulator; COG0784 FOG: CheY-like receiver. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.985 |
