| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00975 | ISM_07340 | Hypothetical protein. | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.594 |
| ISM_07145 | ISM_07340 | NADPH-dependent FMN reductase domain protein; COG0431 Predicted flavoprotein. | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.688 |
| ISM_07145 | ISM_13590 | NADPH-dependent FMN reductase domain protein; COG0431 Predicted flavoprotein. | Hypothetical protein; COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components. | 0.659 |
| ISM_07145 | ISM_16730 | NADPH-dependent FMN reductase domain protein; COG0431 Predicted flavoprotein. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.703 |
| ISM_07340 | ISM_00975 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Hypothetical protein. | 0.594 |
| ISM_07340 | ISM_07145 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | NADPH-dependent FMN reductase domain protein; COG0431 Predicted flavoprotein. | 0.688 |
| ISM_07340 | ISM_07345 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.907 |
| ISM_07340 | ISM_07350 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog. | 0.807 |
| ISM_07340 | ISM_07355 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). | 0.881 |
| ISM_07340 | ISM_13590 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Hypothetical protein; COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components. | 0.611 |
| ISM_07340 | ISM_13635 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | COG0167 Dihydroorotate dehydrogenase. | 0.569 |
| ISM_07340 | ISM_14615 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | NADPH-dependent FMN reductase; COG0431 Predicted flavoprotein. | 0.688 |
| ISM_07340 | ISM_16730 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.861 |
| ISM_07340 | ISM_16740 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.640 |
| ISM_07345 | ISM_07340 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.907 |
| ISM_07345 | ISM_07350 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog. | 0.783 |
| ISM_07345 | ISM_07355 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). | 0.790 |
| ISM_07345 | ISM_13590 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Hypothetical protein; COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components. | 0.414 |
| ISM_07345 | ISM_13635 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | COG0167 Dihydroorotate dehydrogenase. | 0.616 |
| ISM_07345 | ISM_16730 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.674 |