| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00980 | ISM_07345 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.631 |
| ISM_00980 | ISM_07355 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). | 0.453 |
| ISM_00980 | ISM_13635 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | COG0167 Dihydroorotate dehydrogenase. | 0.569 |
| ISM_00980 | ISM_16730 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.870 |
| ISM_05230 | ISM_07345 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.573 |
| ISM_05230 | ISM_13635 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | COG0167 Dihydroorotate dehydrogenase. | 0.569 |
| ISM_05230 | ISM_16730 | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.861 |
| ISM_07335 | ISM_07340 | Transcriptional Regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.532 |
| ISM_07335 | ISM_07345 | Transcriptional Regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.532 |
| ISM_07335 | ISM_07350 | Transcriptional Regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog. | 0.591 |
| ISM_07335 | ISM_07355 | Transcriptional Regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). | 0.607 |
| ISM_07340 | ISM_07335 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Transcriptional Regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | 0.532 |
| ISM_07340 | ISM_07345 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.907 |
| ISM_07340 | ISM_07350 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog. | 0.807 |
| ISM_07340 | ISM_07355 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). | 0.881 |
| ISM_07340 | ISM_13635 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | COG0167 Dihydroorotate dehydrogenase. | 0.569 |
| ISM_07340 | ISM_16730 | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase. | 0.861 |
| ISM_07345 | ISM_00980 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Bacterial luciferase family protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.631 |
| ISM_07345 | ISM_05230 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Hypothetical protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. | 0.573 |
| ISM_07345 | ISM_07335 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Transcriptional Regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. | 0.532 |