| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00215 | ISM_01565 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | 0.966 |
| ISM_00215 | ISM_04775 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.959 |
| ISM_00215 | ISM_05545 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.964 |
| ISM_00215 | ISM_05685 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.991 |
| ISM_00215 | ISM_05910 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.987 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_00215 | ISM_07425 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.958 |
| ISM_00215 | ISM_12885 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.943 |
| ISM_00215 | ISM_12905 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.861 |
| ISM_00215 | ISM_15585 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Phosphate regulon sensor histidine kinase, putative; COG0642 Signal transduction histidine kinase. | 0.577 |
| ISM_01565 | ISM_00215 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.966 |
| ISM_01565 | ISM_04775 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.946 |
| ISM_01565 | ISM_05545 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.971 |
| ISM_01565 | ISM_05685 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.926 |
| ISM_01565 | ISM_05910 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.706 |
| ISM_01565 | ISM_06925 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.897 |
| ISM_01565 | ISM_07425 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.939 |
| ISM_01565 | ISM_12885 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.827 |
| ISM_01565 | ISM_12905 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.844 |
| ISM_01565 | ISM_15585 | Response regulator receiver protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog. | Phosphate regulon sensor histidine kinase, putative; COG0642 Signal transduction histidine kinase. | 0.594 |