| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02060 | ISM_04125 | ISM_02060 | ISM_04125 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.884 |
| ISM_02060 | ISM_06100 | ISM_02060 | ISM_06100 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.451 |
| ISM_02060 | ISM_07955 | ISM_02060 | ISM_07955 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 7-alpha-hydroxysteroid dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.608 |
| ISM_02060 | ISM_08180 | ISM_02060 | ISM_08180 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.772 |
| ISM_02060 | ISM_09496 | ISM_02060 | ISM_09496 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | acetoacetyl-CoA reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.913 |
| ISM_02060 | ISM_16195 | ISM_02060 | ISM_16195 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG0236 Acyl carrier protein. | 0.509 |
| ISM_04125 | ISM_02060 | ISM_04125 | ISM_02060 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.884 |
| ISM_04125 | ISM_06100 | ISM_04125 | ISM_06100 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.451 |
| ISM_04125 | ISM_07955 | ISM_04125 | ISM_07955 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 7-alpha-hydroxysteroid dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.608 |
| ISM_04125 | ISM_08180 | ISM_04125 | ISM_08180 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.772 |
| ISM_04125 | ISM_09496 | ISM_04125 | ISM_09496 | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | acetoacetyl-CoA reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.766 |
| ISM_06100 | ISM_02060 | ISM_06100 | ISM_02060 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.451 |
| ISM_06100 | ISM_04125 | ISM_06100 | ISM_04125 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.451 |
| ISM_06100 | ISM_07955 | ISM_06100 | ISM_07955 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 7-alpha-hydroxysteroid dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.634 |
| ISM_06100 | ISM_08180 | ISM_06100 | ISM_08180 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.465 |
| ISM_06100 | ISM_09496 | ISM_06100 | ISM_09496 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | acetoacetyl-CoA reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.634 |
| ISM_06100 | ISM_16195 | ISM_06100 | ISM_16195 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0236 Acyl carrier protein. | 0.801 |
| ISM_07950 | ISM_07955 | ISM_07950 | ISM_07955 | COG0408 Coproporphyrinogen III oxidase. | 7-alpha-hydroxysteroid dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.774 |
| ISM_07950 | ISM_07960 | ISM_07950 | ISM_07960 | COG0408 Coproporphyrinogen III oxidase. | Methyltransferase, putative; COG2813 16S RNA G1207 methylase RsmC; Belongs to the methyltransferase superfamily. | 0.727 |
| ISM_07950 | clpS | ISM_07950 | ISM_07965 | COG0408 Coproporphyrinogen III oxidase. | ATP-dependent Clp protease, adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.725 |