| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_08275 | ISM_08280 | ISM_08275 | ISM_08280 | Hypothetical protein; COG2994 ACP:hemolysin acyltransferase (hemolysin-activating protein). | Hypothetical protein. | 0.508 |
| ISM_08280 | ISM_08275 | ISM_08280 | ISM_08275 | Hypothetical protein. | Hypothetical protein; COG2994 ACP:hemolysin acyltransferase (hemolysin-activating protein). | 0.508 |
| ISM_08280 | ISM_13435 | ISM_08280 | ISM_13435 | Hypothetical protein. | COG0720 6-pyruvoyl-tetrahydropterin synthase. | 0.844 |
| ISM_08280 | queE | ISM_08280 | ISM_13430 | Hypothetical protein. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.806 |
| ISM_08280 | queF | ISM_08280 | ISM_13425 | Hypothetical protein. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.738 |
| ISM_08280 | ribB | ISM_08280 | ISM_00120 | Hypothetical protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.402 |
| ISM_13435 | ISM_08280 | ISM_13435 | ISM_08280 | COG0720 6-pyruvoyl-tetrahydropterin synthase. | Hypothetical protein. | 0.844 |
| ISM_13435 | queE | ISM_13435 | ISM_13430 | COG0720 6-pyruvoyl-tetrahydropterin synthase. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.999 |
| ISM_13435 | queF | ISM_13435 | ISM_13425 | COG0720 6-pyruvoyl-tetrahydropterin synthase. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.971 |
| queE | ISM_08280 | ISM_13430 | ISM_08280 | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Hypothetical protein. | 0.806 |
| queE | ISM_13435 | ISM_13430 | ISM_13435 | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | COG0720 6-pyruvoyl-tetrahydropterin synthase. | 0.999 |
| queE | queF | ISM_13430 | ISM_13425 | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.979 |
| queF | ISM_08280 | ISM_13425 | ISM_08280 | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | Hypothetical protein. | 0.738 |
| queF | ISM_13435 | ISM_13425 | ISM_13435 | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | COG0720 6-pyruvoyl-tetrahydropterin synthase. | 0.971 |
| queF | queE | ISM_13425 | ISM_13430 | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.979 |
| queF | ribB | ISM_13425 | ISM_00120 | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.565 |
| ribB | ISM_08280 | ISM_00120 | ISM_08280 | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | Hypothetical protein. | 0.402 |
| ribB | queF | ISM_00120 | ISM_13425 | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.565 |