| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00165 | ISM_02060 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.928 |
| ISM_00165 | ISM_08310 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.675 |
| ISM_00165 | ISM_10915 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.869 |
| ISM_00165 | ISM_14750 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG0372 Citrate synthase; Belongs to the citrate synthase family. | 0.810 |
| ISM_00165 | ISM_16740 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.943 |
| ISM_02060 | ISM_00165 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | 0.928 |
| ISM_02060 | ISM_06100 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.613 |
| ISM_02060 | ISM_08310 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.771 |
| ISM_02060 | ISM_08315 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | 0.666 |
| ISM_02060 | ISM_10915 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.880 |
| ISM_02060 | ISM_11415 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.743 |
| ISM_02060 | ISM_14750 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG0372 Citrate synthase; Belongs to the citrate synthase family. | 0.935 |
| ISM_02060 | ISM_16740 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.971 |
| ISM_05875 | ISM_08310 | phenylacetate-CoA ligase, putative; COG1541 Coenzyme F390 synthetase. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.729 |
| ISM_05875 | ISM_10915 | phenylacetate-CoA ligase, putative; COG1541 Coenzyme F390 synthetase. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.730 |
| ISM_05875 | ISM_16740 | phenylacetate-CoA ligase, putative; COG1541 Coenzyme F390 synthetase. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.552 |
| ISM_06100 | ISM_02060 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.613 |
| ISM_06100 | ISM_08310 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.675 |
| ISM_06100 | ISM_10915 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.675 |
| ISM_06100 | ISM_11415 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.765 |