Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_08705HAD-superfamily hydrolase, subfamily IA, variant 1 family protein; COG1011 Predicted hydrolase (HAD superfamily). (205 aa)    
Predicted Functional Partners:
ISM_08695
Putative alpha/beta hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
  
 
  0.863
ISM_00795
Haloacid dehalogenase, type II; COG1011 Predicted hydrolase (HAD superfamily).
     
  0.850
ISM_08700
Ornithine cyclodeaminase/mu-crystallin family protein; COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog.
       0.845
ISM_08710
Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
       0.773
ISM_09180
COG1012 NAD-dependent aldehyde dehydrogenases.
     
  0.773
ISM_12055
COG1012 NAD-dependent aldehyde dehydrogenases.
     
  0.773
ISM_13030
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
    
 0.721
ISM_08715
COG1671 Uncharacterized protein conserved in bacteria; Belongs to the UPF0178 family.
       0.655
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.645
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
 0.633
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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