| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00820 | ISM_08725 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG1062 Zn-dependent alcohol dehydrogenases, class III. | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. | 0.992 |
| ISM_02320 | ISM_08725 | Glutathione-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. | 0.999 |
| ISM_04865 | ISM_04870 | COG2864 Cytochrome b subunit of formate dehydrogenase. | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.998 |
| ISM_04865 | ISM_04875 | COG2864 Cytochrome b subunit of formate dehydrogenase. | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.994 |
| ISM_04865 | ISM_06040 | COG2864 Cytochrome b subunit of formate dehydrogenase. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.890 |
| ISM_04865 | ISM_07715 | COG2864 Cytochrome b subunit of formate dehydrogenase. | Formate dehydrogenase, alpha subunit; COG3383 Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.963 |
| ISM_04865 | ISM_08725 | COG2864 Cytochrome b subunit of formate dehydrogenase. | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. | 0.850 |
| ISM_04870 | ISM_04865 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | COG2864 Cytochrome b subunit of formate dehydrogenase. | 0.998 |
| ISM_04870 | ISM_04875 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.992 |
| ISM_04870 | ISM_06040 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.906 |
| ISM_04870 | ISM_07715 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Formate dehydrogenase, alpha subunit; COG3383 Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.957 |
| ISM_04870 | ISM_08725 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. | 0.850 |
| ISM_04875 | ISM_04865 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | COG2864 Cytochrome b subunit of formate dehydrogenase. | 0.994 |
| ISM_04875 | ISM_04870 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.992 |
| ISM_04875 | ISM_06040 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.996 |
| ISM_04875 | ISM_07715 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Formate dehydrogenase, alpha subunit; COG3383 Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.885 |
| ISM_04875 | ISM_08725 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. | 0.857 |
| ISM_06040 | ISM_04865 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | COG2864 Cytochrome b subunit of formate dehydrogenase. | 0.890 |
| ISM_06040 | ISM_04870 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.906 |
| ISM_06040 | ISM_04875 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.996 |