Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ISM_08800NAD(P)H dehydrogenase, quinone family protein; COG2249 Putative NADPH-quinone reductase (modulator of drug activity B). (172 aa)    
Predicted Functional Partners:
ISM_08795
Transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator.
 
     0.897
ISM_17225
Glutathione-regulated potassium-efflux system protein; COG0475 Kef-type K+ transport systems, membrane components.
  
 
 0.891
ISM_08015
COG2249 Putative NADPH-quinone reductase (modulator of drug activity B).
  
  
  0.748
ISM_00255
Tryptophan repressor binding protein; COG0655 Multimeric flavodoxin WrbA.
    
 0.661
ISM_14290
COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases; Belongs to the complex I 20 kDa subunit family.
    
   0.569
ISM_02335
Methyltransferase, UbiE/COQ5 family protein; COG0500 SAM-dependent methyltransferases.
     
  0.526
ubiE
Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
     
  0.526
ISM_16570
2-heptaprenyl-1,4-naphthoquinone methyltransferase (menaquinonebiosynthesis methyltransferase); COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis.
     
  0.526
ISM_16925
Hypothetical protein; COG1226 Kef-type K+ transport systems, predicted NAD-binding component.
   
 
 0.402
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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