Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ISM_08965COG0347 Nitrogen regulatory protein PII. (112 aa)    
Predicted Functional Partners:
ISM_08960
Ammonium transporter; COG0004 Ammonia permease.
 0.992
ISM_08160
Ammonium transporter; COG0004 Ammonia permease.
 
 0.963
glnD
protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
 
 0.940
ISM_16640
Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific.
  
 0.919
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
  
 
 
 0.848
ISM_00035
Hypothetical protein; COG0457 FOG: TPR repeat.
    
 
 0.766
ISM_13590
Hypothetical protein; COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components.
   
 
 0.750
ISM_05405
COG0174 Glutamine synthetase.
 
 
 0.651
tauB
Taurine ABC transporter, ATP-binding protein; Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.
    
 
 0.618
ISM_13605
ABC transporter, ATP-binding protein; COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component.
    
 
 0.618
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.