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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_08965COG0347 Nitrogen regulatory protein PII. (112 aa)    
Predicted Functional Partners:
ISM_08960
Ammonium transporter; COG0004 Ammonia permease.
 0.997
ISM_08160
Ammonium transporter; COG0004 Ammonia permease.
 
 0.987
ISM_16640
Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific.
  
 0.978
glnD
protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
 
 0.956
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
  
 
 
 0.948
ISM_00035
Hypothetical protein; COG0457 FOG: TPR repeat.
    
 
 0.937
ISM_06100
Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1.
     
 0.613
ISM_08970
Penicillin-binding protein, 1A family protein; COG0744 Membrane carboxypeptidase (penicillin-binding protein).
       0.532
nadE
NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.489
ISM_08975
COG3228 Uncharacterized protein conserved in bacteria; Belongs to the MtfA family.
       0.478
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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