STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_09886Aminotransferase family protein; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. (375 aa)    
Predicted Functional Partners:
ISM_09876
Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators.
       0.669
ISM_09881
Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators.
       0.669
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.630
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
    0.573
ISM_09150
FAD dependent oxidoreductase/aminomethyl transferase; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
 
 
 0.560
ISM_04010
Putative glycolate oxidase; COG0277 FAD/FMN-containing dehydrogenases.
  
 
 0.541
ISM_10261
Putative oxidoreductase protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
 
 
 0.535
ISM_02920
FAD dependent oxidoreductase/aminomethyl transferase; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
 
 
 0.524
ISM_04390
Aminomethyl transferase family protein; COG0665 Glycine/D-amino acid oxidases (deaminating); Belongs to the GcvT family.
 
 
 0.522
ISM_04300
Putative aminomethyltransferase protein; Belongs to the GcvT family.
   
 
  0.513
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.