Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_10006Hypothetical protein; COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Belongs to the UPF0102 family. (165 aa)    
Predicted Functional Partners:
rsmI
Tetrapyrrole methylase family protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
       0.801
gshB
COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family.
       0.724
ISM_10016
Esterase, putative; COG0657 Esterase/lipase.
       0.716
ISM_09996
Hypothetical protein; COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component.
       0.659
glnD
protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
       0.645
ISM_05265
Diguanylate cyclase, putative; COG2200 FOG: EAL domain.
   
    0.508
ISM_07920
COG1846 Transcriptional regulators.
  
    0.471
ISM_13150
Transcriptional regulator, MarR family protein; COG1846 Transcriptional regulators.
  
    0.460
nadE
NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
 
     0.432
ISM_08900
ATP synthase F0, subunit I; A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.
  
     0.416
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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