| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_09185 | ISM_10381 | ISM_09185 | ISM_10381 | Thiol-specific antioxidant protein; COG0450 Peroxiredoxin. | COG0526 Thiol-disulfide isomerase and thioredoxins. | 0.579 |
| ISM_10381 | ISM_09185 | ISM_10381 | ISM_09185 | COG0526 Thiol-disulfide isomerase and thioredoxins. | Thiol-specific antioxidant protein; COG0450 Peroxiredoxin. | 0.579 |
| ISM_10381 | ISM_13230 | ISM_10381 | ISM_13230 | COG0526 Thiol-disulfide isomerase and thioredoxins. | COG2010 Cytochrome c, mono- and diheme variants. | 0.402 |
| ISM_10381 | ISM_14885 | ISM_10381 | ISM_14885 | COG0526 Thiol-disulfide isomerase and thioredoxins. | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | 0.588 |
| ISM_10381 | apt | ISM_10381 | ISM_01435 | COG0526 Thiol-disulfide isomerase and thioredoxins. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.461 |
| ISM_10381 | msrA-3 | ISM_10381 | ISM_10386 | COG0526 Thiol-disulfide isomerase and thioredoxins. | Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.666 |
| ISM_10381 | msrB | ISM_10381 | ISM_10391 | COG0526 Thiol-disulfide isomerase and thioredoxins. | Methionine sulfoxide reductase B; COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase. | 0.503 |
| ISM_10381 | rplA | ISM_10381 | ISM_01910 | COG0526 Thiol-disulfide isomerase and thioredoxins. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.417 |
| ISM_10381 | tmk | ISM_10381 | ISM_00850 | COG0526 Thiol-disulfide isomerase and thioredoxins. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.713 |
| ISM_13230 | ISM_10381 | ISM_13230 | ISM_10381 | COG2010 Cytochrome c, mono- and diheme variants. | COG0526 Thiol-disulfide isomerase and thioredoxins. | 0.402 |
| ISM_13230 | ISM_14885 | ISM_13230 | ISM_14885 | COG2010 Cytochrome c, mono- and diheme variants. | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | 0.715 |
| ISM_14885 | ISM_10381 | ISM_14885 | ISM_10381 | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | COG0526 Thiol-disulfide isomerase and thioredoxins. | 0.588 |
| ISM_14885 | ISM_13230 | ISM_14885 | ISM_13230 | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | COG2010 Cytochrome c, mono- and diheme variants. | 0.715 |
| ISM_14885 | apt | ISM_14885 | ISM_01435 | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.762 |
| apt | ISM_10381 | ISM_01435 | ISM_10381 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | COG0526 Thiol-disulfide isomerase and thioredoxins. | 0.461 |
| apt | ISM_14885 | ISM_01435 | ISM_14885 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | 0.762 |
| msrA-3 | ISM_10381 | ISM_10386 | ISM_10381 | Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | COG0526 Thiol-disulfide isomerase and thioredoxins. | 0.666 |
| msrA-3 | msrB | ISM_10386 | ISM_10391 | Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | Methionine sulfoxide reductase B; COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase. | 0.993 |
| msrB | ISM_10381 | ISM_10391 | ISM_10381 | Methionine sulfoxide reductase B; COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase. | COG0526 Thiol-disulfide isomerase and thioredoxins. | 0.503 |
| msrB | msrA-3 | ISM_10391 | ISM_10386 | Methionine sulfoxide reductase B; COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase. | Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.993 |