| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01215 | ISM_03740 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.500 |
| ISM_01215 | ISM_03750 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.817 |
| ISM_01215 | ISM_03765 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.484 |
| ISM_01215 | ISM_04770 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.723 |
| ISM_01215 | ISM_04790 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein rsbU; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.834 |
| ISM_01215 | ISM_06925 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.944 |
| ISM_01215 | ISM_07925 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.475 |
| ISM_01215 | ISM_10556 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.915 |
| ISM_01215 | ISM_13540 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.450 |
| ISM_01215 | ISM_15615 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Phosphate regulon transcriptional regulatory protein PhoB; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.440 |
| ISM_03740 | ISM_01215 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.500 |
| ISM_03740 | ISM_03750 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.503 |
| ISM_03740 | ISM_04770 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.818 |
| ISM_03740 | ISM_06925 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.935 |
| ISM_03740 | ISM_07925 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.631 |
| ISM_03740 | ISM_10556 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Hypothetical protein; COG0642 Signal transduction histidine kinase. | 0.913 |
| ISM_03740 | ISM_13540 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.670 |
| ISM_03750 | ISM_01215 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.817 |
| ISM_03750 | ISM_03740 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.503 |
| ISM_03750 | ISM_04770 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.831 |