node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ISM_09816 | xsc | ISM_09816 | ISM_10690 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Catalyzes the degradation of sulfoacetaldehyde into sulfite and acetyl phosphate. Involved in sulfolactate degradation. | 0.916 |
ISM_10680 | ISM_15265 | ISM_10680 | ISM_15265 | COG1171 Threonine dehydratase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.890 |
ISM_10680 | ilvC | ISM_10680 | ISM_09871 | COG1171 Threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.544 |
ISM_10680 | leuB | ISM_10680 | ISM_10241 | COG1171 Threonine dehydratase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.939 |
ISM_10680 | xsc | ISM_10680 | ISM_10690 | COG1171 Threonine dehydratase. | Hypothetical protein; Catalyzes the degradation of sulfoacetaldehyde into sulfite and acetyl phosphate. Involved in sulfolactate degradation. | 0.686 |
ISM_10695 | ISM_10700 | ISM_10695 | ISM_10700 | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.681 |
ISM_10695 | ISM_10705 | ISM_10695 | ISM_10705 | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.544 |
ISM_10695 | ISM_10710 | ISM_10695 | ISM_10710 | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | Dimethyl sulfoxide reductase, C subunit, putative; COG3302 DMSO reductase anchor subunit. | 0.483 |
ISM_10695 | ISM_15265 | ISM_10695 | ISM_15265 | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.507 |
ISM_10695 | xsc | ISM_10695 | ISM_10690 | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | Hypothetical protein; Catalyzes the degradation of sulfoacetaldehyde into sulfite and acetyl phosphate. Involved in sulfolactate degradation. | 0.920 |
ISM_10700 | ISM_10695 | ISM_10700 | ISM_10695 | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | 0.681 |
ISM_10700 | ISM_10705 | ISM_10700 | ISM_10705 | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.999 |
ISM_10700 | ISM_10710 | ISM_10700 | ISM_10710 | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Dimethyl sulfoxide reductase, C subunit, putative; COG3302 DMSO reductase anchor subunit. | 0.997 |
ISM_10700 | xsc | ISM_10700 | ISM_10690 | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Hypothetical protein; Catalyzes the degradation of sulfoacetaldehyde into sulfite and acetyl phosphate. Involved in sulfolactate degradation. | 0.738 |
ISM_10705 | ISM_10695 | ISM_10705 | ISM_10695 | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | 0.544 |
ISM_10705 | ISM_10700 | ISM_10705 | ISM_10700 | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.999 |
ISM_10705 | ISM_10710 | ISM_10705 | ISM_10710 | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Dimethyl sulfoxide reductase, C subunit, putative; COG3302 DMSO reductase anchor subunit. | 0.996 |
ISM_10705 | ISM_13335 | ISM_10705 | ISM_13335 | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Sulfopyruvate decarboxylase subunit alpha; COG4032 Predicted thiamine-pyrophosphate-binding protein. | 0.495 |
ISM_10705 | xsc | ISM_10705 | ISM_10690 | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Hypothetical protein; Catalyzes the degradation of sulfoacetaldehyde into sulfite and acetyl phosphate. Involved in sulfolactate degradation. | 0.708 |
ISM_10710 | ISM_10695 | ISM_10710 | ISM_10695 | Dimethyl sulfoxide reductase, C subunit, putative; COG3302 DMSO reductase anchor subunit. | Phosphate acetyltransferase; COG0280 Phosphotransacetylase. | 0.483 |