| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_04870 | ISM_04900 | ISM_04870 | ISM_04900 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | 0.962 |
| ISM_04870 | ISM_06040 | ISM_04870 | ISM_06040 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.906 |
| ISM_04870 | ISM_08760 | ISM_04870 | ISM_08760 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Thiosulfate sulfurtransferase, putative; COG2897 Rhodanese-related sulfurtransferase. | 0.639 |
| ISM_04870 | ISM_10426 | ISM_04870 | ISM_10426 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | COG3258 Cytochrome c. | 0.902 |
| ISM_04870 | ISM_10456 | ISM_04870 | ISM_10456 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | COG2010 Cytochrome c, mono- and diheme variants. | 0.885 |
| ISM_04870 | ISM_10700 | ISM_04870 | ISM_10700 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.967 |
| ISM_04870 | ISM_10710 | ISM_04870 | ISM_10710 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Dimethyl sulfoxide reductase, C subunit, putative; COG3302 DMSO reductase anchor subunit. | 0.826 |
| ISM_04870 | ISM_15735 | ISM_04870 | ISM_15735 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.624 |
| ISM_04870 | cysC | ISM_04870 | ISM_11065 | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.909 |
| ISM_04900 | ISM_04870 | ISM_04900 | ISM_04870 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.962 |
| ISM_04900 | ISM_06040 | ISM_04900 | ISM_06040 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.952 |
| ISM_04900 | ISM_08760 | ISM_04900 | ISM_08760 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Thiosulfate sulfurtransferase, putative; COG2897 Rhodanese-related sulfurtransferase. | 0.437 |
| ISM_04900 | ISM_10700 | ISM_04900 | ISM_10700 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Oxidoreductase, molybdopterin-binding; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.949 |
| ISM_04900 | ISM_10705 | ISM_04900 | ISM_10705 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Iron-sulfur cluster-binding protein; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.821 |
| ISM_04900 | ISM_10710 | ISM_04900 | ISM_10710 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Dimethyl sulfoxide reductase, C subunit, putative; COG3302 DMSO reductase anchor subunit. | 0.548 |
| ISM_04900 | cysC | ISM_04900 | ISM_11065 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.434 |
| ISM_06040 | ISM_04870 | ISM_06040 | ISM_04870 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | Formate dehydrogenase, iron-sulfur subunit, putative; COG0437 Fe-S-cluster-containing hydrogenase components 1. | 0.906 |
| ISM_06040 | ISM_04900 | ISM_06040 | ISM_04900 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | 0.952 |
| ISM_06040 | ISM_08760 | ISM_06040 | ISM_08760 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | Thiosulfate sulfurtransferase, putative; COG2897 Rhodanese-related sulfurtransferase. | 0.456 |
| ISM_06040 | ISM_10426 | ISM_06040 | ISM_10426 | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | COG3258 Cytochrome c. | 0.930 |