| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_04300 | ISM_10800 | ISM_04300 | ISM_10800 | Putative aminomethyltransferase protein; Belongs to the GcvT family. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.422 |
| ISM_07270 | ISM_10800 | ISM_07270 | ISM_10800 | COG0863 DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.526 |
| ISM_07555 | ISM_10800 | ISM_07555 | ISM_10800 | TRAG protein; COG3505 Type IV secretory pathway, VirD4 components. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.594 |
| ISM_07555 | ISM_17825 | ISM_07555 | ISM_17825 | TRAG protein; COG3505 Type IV secretory pathway, VirD4 components. | Type IV secretion system coupling protein; COG3505 Type IV secretory pathway, VirD4 components. | 0.700 |
| ISM_10795 | ISM_10800 | ISM_10795 | ISM_10800 | Hypothetical protein. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.508 |
| ISM_10800 | ISM_04300 | ISM_10800 | ISM_04300 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Putative aminomethyltransferase protein; Belongs to the GcvT family. | 0.422 |
| ISM_10800 | ISM_07270 | ISM_10800 | ISM_07270 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | COG0863 DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family. | 0.526 |
| ISM_10800 | ISM_07555 | ISM_10800 | ISM_07555 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | TRAG protein; COG3505 Type IV secretory pathway, VirD4 components. | 0.594 |
| ISM_10800 | ISM_10795 | ISM_10800 | ISM_10795 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Hypothetical protein. | 0.508 |
| ISM_10800 | ISM_11115 | ISM_10800 | ISM_11115 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Hypothetical protein. | 0.490 |
| ISM_10800 | ISM_12755 | ISM_10800 | ISM_12755 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Hypothetical protein; COG3747 Phage terminase, small subunit. | 0.483 |
| ISM_10800 | ISM_12760 | ISM_10800 | ISM_12760 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | COG4626 Phage terminase-like protein, large subunit. | 0.467 |
| ISM_10800 | ISM_17295 | ISM_10800 | ISM_17295 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Hypothetical protein. | 0.594 |
| ISM_10800 | ISM_17825 | ISM_10800 | ISM_17825 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Type IV secretion system coupling protein; COG3505 Type IV secretory pathway, VirD4 components. | 0.594 |
| ISM_10800 | cysC | ISM_10800 | ISM_11065 | HNH endonuclease family protein; COG1403 Restriction endonuclease. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.429 |
| ISM_11115 | ISM_10800 | ISM_11115 | ISM_10800 | Hypothetical protein. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.490 |
| ISM_12755 | ISM_10800 | ISM_12755 | ISM_10800 | Hypothetical protein; COG3747 Phage terminase, small subunit. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.483 |
| ISM_12755 | ISM_12760 | ISM_12755 | ISM_12760 | Hypothetical protein; COG3747 Phage terminase, small subunit. | COG4626 Phage terminase-like protein, large subunit. | 0.965 |
| ISM_12760 | ISM_10800 | ISM_12760 | ISM_10800 | COG4626 Phage terminase-like protein, large subunit. | HNH endonuclease family protein; COG1403 Restriction endonuclease. | 0.467 |
| ISM_12760 | ISM_12755 | ISM_12760 | ISM_12755 | COG4626 Phage terminase-like protein, large subunit. | Hypothetical protein; COG3747 Phage terminase, small subunit. | 0.965 |
