STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_10890Glutamate--cysteine ligase family protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (377 aa)    
Predicted Functional Partners:
ISM_08205
Hypothetical protein.
   
  0.949
gshB
COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family.
    
 0.812
ISM_05945
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
    
  0.784
ISM_07330
COG0518 GMP synthase - Glutamine amidotransferase domain.
 
     0.698
ISM_10156
Gamma-glutamyltranspeptidase, putative; COG0405 Gamma-glutamyltransferase.
    
 0.640
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
     
 0.628
ISM_10685
COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
     
 0.628
ISM_11405
Possible gamma-glutamyltranspeptidase precursor; COG0405 Gamma-glutamyltransferase.
    
 0.589
ISM_14460
Gamma-glutamyltranspeptidase; COG0405 Gamma-glutamyltransferase.
    
 0.589
ISM_10895
Hypothetical protein.
       0.578
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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