| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00165 | ISM_09180 | ISM_00165 | ISM_09180 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.797 |
| ISM_00165 | ISM_09576 | ISM_00165 | ISM_09576 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.857 |
| ISM_00165 | ISM_10875 | ISM_00165 | ISM_10875 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Belongs to the HIBADH-related family. | 0.639 |
| ISM_00165 | ISM_10915 | ISM_00165 | ISM_10915 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.824 |
| ISM_00165 | ISM_12055 | ISM_00165 | ISM_12055 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.716 |
| ISM_00165 | ISM_12940 | ISM_00165 | ISM_12940 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. | 0.639 |
| ISM_00165 | ISM_14240 | ISM_00165 | ISM_14240 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.857 |
| ISM_00165 | ISM_16580 | ISM_00165 | ISM_16580 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | 6-phosphogluconate dehydrogenase domain protein; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. | 0.639 |
| ISM_00165 | ISM_16820 | ISM_00165 | ISM_16820 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.851 |
| ISM_00165 | acsA | ISM_00165 | ISM_01255 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.857 |
| ISM_09180 | ISM_00165 | ISM_09180 | ISM_00165 | COG1012 NAD-dependent aldehyde dehydrogenases. | Oxidoreductase, zinc-binding dehydrogenase family protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. | 0.797 |
| ISM_09180 | ISM_09576 | ISM_09180 | ISM_09576 | COG1012 NAD-dependent aldehyde dehydrogenases. | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.659 |
| ISM_09180 | ISM_10875 | ISM_09180 | ISM_10875 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Belongs to the HIBADH-related family. | 0.668 |
| ISM_09180 | ISM_10915 | ISM_09180 | ISM_10915 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.801 |
| ISM_09180 | ISM_12055 | ISM_09180 | ISM_12055 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.662 |
| ISM_09180 | ISM_12940 | ISM_09180 | ISM_12940 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. | 0.668 |
| ISM_09180 | ISM_14240 | ISM_09180 | ISM_14240 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.665 |
| ISM_09180 | ISM_16580 | ISM_09180 | ISM_16580 | COG1012 NAD-dependent aldehyde dehydrogenases. | 6-phosphogluconate dehydrogenase domain protein; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. | 0.666 |
| ISM_09180 | ISM_16820 | ISM_09180 | ISM_16820 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.641 |
| ISM_09180 | acsA | ISM_09180 | ISM_01255 | COG1012 NAD-dependent aldehyde dehydrogenases. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.665 |