| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_06540 | ISM_08250 | ISM_06540 | ISM_08250 | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | COG3938 Proline racemase; Belongs to the proline racemase family. | 0.739 |
| ISM_06540 | ISM_08325 | ISM_06540 | ISM_08325 | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.780 |
| ISM_06540 | ISM_14525 | ISM_06540 | ISM_14525 | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog. | 0.850 |
| ISM_06540 | proC | ISM_06540 | ISM_11120 | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.773 |
| ISM_06960 | ISM_08325 | ISM_06960 | ISM_08325 | Membrane protein, putative; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.633 |
| ISM_06960 | proC | ISM_06960 | ISM_11120 | Membrane protein, putative; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.561 |
| ISM_08250 | ISM_06540 | ISM_08250 | ISM_06540 | COG3938 Proline racemase; Belongs to the proline racemase family. | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | 0.739 |
| ISM_08250 | ISM_08325 | ISM_08250 | ISM_08325 | COG3938 Proline racemase; Belongs to the proline racemase family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.798 |
| ISM_08250 | ISM_14525 | ISM_08250 | ISM_14525 | COG3938 Proline racemase; Belongs to the proline racemase family. | COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog. | 0.670 |
| ISM_08250 | proC | ISM_08250 | ISM_11120 | COG3938 Proline racemase; Belongs to the proline racemase family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.654 |
| ISM_08325 | ISM_06540 | ISM_08325 | ISM_06540 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | 0.780 |
| ISM_08325 | ISM_06960 | ISM_08325 | ISM_06960 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Membrane protein, putative; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | 0.633 |
| ISM_08325 | ISM_08250 | ISM_08325 | ISM_08250 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG3938 Proline racemase; Belongs to the proline racemase family. | 0.798 |
| ISM_08325 | ISM_14525 | ISM_08325 | ISM_14525 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog. | 0.865 |
| ISM_08325 | proA | ISM_08325 | ISM_16110 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.876 |
| ISM_08325 | proB | ISM_08325 | ISM_16115 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.884 |
| ISM_08325 | proC | ISM_08325 | ISM_11120 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.893 |
| ISM_11115 | ISM_11125 | ISM_11115 | ISM_11125 | Hypothetical protein. | Chaperonin csaA; COG0073 EMAP domain. | 0.807 |
| ISM_11115 | ISM_11130 | ISM_11115 | ISM_11130 | Hypothetical protein. | D-isomer specific 2-hydroxyacid dehydrogenase family protein; COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.737 |
| ISM_11115 | proC | ISM_11115 | ISM_11120 | Hypothetical protein. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.755 |
